Projects & Publications

The following research projects have been supported through NIH U01 grant and collaborative research agreements between ˿��Ƶ and the Mayo Clinic in Rochester, Minnesota.

Investigating the characteristics of doped diamond materials for fast cycle biosensing applications

Relevant publications:

F.S. Manciu, Y. Oh, A.S. Barath, A.E. Rusheen, A.Z. Kouzani, D.R. Hodges, J. Guerrero, J.R. Tomshine, K.H. Lee, K.E. Bennet. Analysis of Carbon-based Microelectrodes for Neurochemical Sensing. Materials, 12(19), 3186–3199, PMID: 31569398 (2019).
K.E. Bennet, J. Tomshine, P. Min, F.S. Manciu, M. Marsh, B. Paek, M. Settell, E. Nicolai, C.D. Blaha, A.Z. Kouzani, S.-Y. Chang, K.H. Lee: “A Diamond-Based Electrode for Detection of Neurotransmitters in the Human Brain”, Frontiers in Human Neuroscience, vol. 10 doi: 10.3389/fnhum.2016.00102 (2016).
K.E. Bennet, K.H. Lee, J.R. Tomshine, E.M. Sundin, J.N. Kruchowski, W.G. Durrer, B.M. Manciu, A. Kouzani, F.S. Manciu: “Raman microscopic analysis of internal stress in boron-doped diamond”, Materials vol. 8, 2782–2793; DOI:10.3390/ma8052782 (2015).
Md K. Hosain, A.Z. Kouzani, S.J. Tye, Mst F. Samad, R. Kale, K. Bennet, F.S. Manciu, M. Berk: “Radio Frequency Energy Harvesting from a Feeding Source in a Passive Deep Brain Stimulation Device for Murine Preclinical Research”, Medical Engineering & Physics, vol. 37, 1020–1026 (2015).
F.S. Manciu, M. Manciu, W.G. Durrer, J.G. Salazar, K. H. Lee, K.E. Bennet: “A Drude model analysis of conductivity and free carriers in boron-doped diamond films and investigations of their internal stress and strain”, Journal of Materials Science vol. 49, 5782–5789, DOI:10.1007/s10853-014-8309-x (2014).
K.E. Bennet, K.H. Lee, J.N. Kruchowski, S.Y. Chang, M.P. Marsh, A.A. Van Orsow, A. Paez, F.S. Manciu: “Development of Conductive Boron-Doped Diamond Electrode: a Microscopic, Spectroscopic, and Voltammetric Study” Materials, vol. 6, 5726-5741, (2013).

Optical detection of neurotransmitters by confocal Raman

Relevant publication:

F.S. Manciu, M. Manciu, J.D. Ciubuc, E.M. Sundin, K. Ochoa, M. Eastman, W.G. Durrer, J. Guerrero, B. Lopez, M. Subedi, K.E. Bennet. Simultaneous Detection of Dopamine and Serotonin – a Comparative Experimental and Theoretical Study of Neurotransmitter Interactions. Biosensors, 9(1), 3 PMID: 30587770, PMCID: PMC6468865 (2019).
E.M. Sundin, J.D. Ciubuc, K.E. Bennet, K. Ochoa, F.S. Manciu. Comparative Computational and Experimental Detection of Adenosine Using Ultrasensitive Surface-Enhanced Raman Spectroscopy. Sensors, 18(8), 2696–2711, PIMD: 30115871, PMCID: PMC6111885 (2018).
F.S. Manciu, J.D. Ciubuc, E.M. Sundin, C. Qiu, K.E. Bennet. Analysis of Serotonin Molecules on Silver Nanocolloids – a Raman Computational and Experimental Study. Sensors, 17(7), 1471–1482, PMID: 28640186, PMCID: PMC5539499 (2017).
J.D. Ciubuc, C. Qiu, K.E. Bennet, M. Alonzo, W.G. Durrer, F.S. Manciu. Raman Computational and Experimental Studies of Dopamine Detection. Biosensors, 17, 43–55, PMID: 28956820 (2017).
C. Qiu, K.E. Bennet, J.R. Tomshine, S. Hara, J.D. Ciubuc, U. Schmidt, W.G. Durrer, M.B. McIntosh, M. Eastman, F.S. Manciu. Ultrasensitive detection of neurotransmitters by surface enhanced Raman spectroscopy for biosensing applications. Biointerface Research in Applied Chemistry, 7(1), 1921-1926 (2017).
C. Qiu, K.E. Bennet, T. Khan, J.D. Ciubuc, F.S. Manciu. Raman and Conductivity Analysis of Graphene for Biomedical Applications. Materials, 9(11), 897–908 (2016).
F.S. Manciu, K.H. Lee, W.G. Durrer, K.E. Bennet: “Detection and Monitoring of Neurotransmitters - a Spectroscopic Analysis” Neuromodulation vol. 16(3),192-198 DOI: 10.1111/j.1525-1403.2012.00502.x (2013).

The following research projects are based on internal collaborative efforts .

Bioimaging analysis of cancer cells and tissue

Relevant publication:

J.D. Ciubuc, M. Manciu, A. Maran, M.J. Yaszemski, E.M. Sundin, K.E. Bennet, F.S. Manciu. Raman Spectroscopic and Microscopic Analysis for Monitoring Renal Osteodystrophy Signatures. Biosensors, 8, 38–49, PMID: 29642494, PMCID: PMC6022865 (2018).
F.S. Manciu, J.D. Ciubuc, K. Parra, M. Manciu, K.E. Bennet, P. Valenzuela, E.M. Sundin, W.G. Durrer, L. Reza, G. Francia: “Label-free Raman imaging to monitor breast tumor signatures”, Technology in Cancer Research & Treatment, 16(4),461-469,PMID:27381847 (2017).

Gaining new insights into the formation and prevention of kidney stones

Relevant publications:

F.S. Manciu, J.D. Ciubuc, K. Ochoa, P. Dacha, M. Subedi, J. Guerrero, M. Eastman, D.R. Hodges, K.E. Bennet. Comparative spectroscopic analysis of nordihydroguaiaretic acid and related natural products to inhibition of calcium oxalate calculi. Biointerface Research in Applied Chemistry, 9(3), 3942–3948 (2019).
L.A. Pinales, R.R. Chianelli, W.G. Durrer, R. Pal, M. Narayan, F.S. Manciu: “Spectroscopic study of inhibition of calcium oxalate calculi growth by Larrea Tridentata”, Journal of Raman Spectroscopy, vol. 42(3), 259-264 (2011).
F.S. Manciu, J.R. Govani, W.G. Durrer, L. Reza, L.A. Pinales: “Inhibition of urinary calculi – a spectroscopic study”, Journal of Raman Spectroscopy, vol. 40(8), 861-865 (2009).

Exploring ways of improving the characteristics of oxide materials for sensor development

Relevant publications:

N. Makeswaran, A.K. Battu, R. Swadipta, F.S. Manciu, C.V. Ramana. Spectroscopic Characterization of the Electronic Structure, Chemical Bonding, and Band Gap in Thermally Annealed Polycrystalline Ga2O3 Thin Films. ECS Journal of Solid State Science and Technology, 8(7), Q3249–Q3253 (2019).
R. Baral, H.S. Fierro, C. Rueda, B. Sahu, A.M. Strydom, N. Poudel, K. Gofryk, F.S. Manciu, C. Ritter, T.W. Heitmann, B.P. Belbase, S. Bati, M.P. Ghimire, and H.S. Nair₸. Signatures of low-dimensional magnetism and short-range magnetic order in Co-based trirutiles. Phys. Rev. B, 100, 184407 (2019).
E.M. Deemer, P.K. Paul, F.S. Manciu, C.E. Botez, D.R. Hodges, Z. Landis, T. Akter, E. Castro, R.R. Chianelli. Consequence of oxidation method on graphene oxide produced with different size graphite precursors. Materials Science & Engineering B, 224, 150–157 (2017).
U. Ramabadran, G. Ryan, X. Zhou, S. Farhat, F. Manciu, Y. Tong, R. Ayler, G. Garner. Reduced Graphene Oxide on Nickel Foam for Supercapacitor Electrodes. Materials, 10(11), 1295–1311 (2017).
T.N. Nunley, T.I. Willett-Gies, J.A. Cooke, F.S. Manciu, P. Marsik, C. Bernhard, S. Zollner. Optical constants, band gap, and infrared-active phonons of (LaAlO3)0.3(Sr2AlTaO6)0.35 (LSAT) from spectroscopic ellipsometry. Journal of Vacuum Science & Technology A, 34, 051507 (2016).
F.S. Manciu, Y. Yun, W.G. Durrer, U. Schmidt, J. Howard, C.V. Ramana: “Spectroscopic analysis of temperature dependent growth of WO3 and W0.95Ti0.05O3 thin films”, Journal of Materials Science, vol. 47(18), 6593-6600 (2012).
N.R. Kalidindi, F.S. Manciu, C.V. Ramana: “Effect of Temperature on the Growth, Microstructure of W0.95Tu0.05O3 Thin Films”, ACS Applied Materials & Interfaces, vol. 3(3), 863-868 (2011).
F.S. Manciu, J.L. Enriquez, W.G. Durrer, Y. Yun, C.V. Ramana, S.K. Gullapalli: “Spectroscopic analysis of tungsten oxide thin films”, Journal of Materials Research, vol. 25(12), 2401-2406 (2010).
S.K. Gullapalli, F.S. Manciu, J.L. Enriquez, C.V. Ramana: “Tungsten Oxide (WO3) Thin Films for Application in Advanced Energy Systems”, Journal of Vacuum Science and Technology A, vol. 28(4), 824-828 (2010).

Characterizing highly energetic solid materials for use as rocket fuels

This research was supported by a Department of Defense – Missile Defense Agency (DOD-MDA) award and was based on collaborative efforts with the Department of Mechanical Engineering at ˿��Ƶ, particularly with Dr. Ahsan Choudhuri and Dr. Arturo Bronson. It also aided the broadening of the research collaboration with the Brookhaven National Laboratory, the Metal Hydrides Center of Excellence – specifically with Dr. James Wegrzyn, Dr. Jason Graetz, and Dr. David Lacina.

Relevant publication:

F.S. Manciu, L. Reza, W.G. Durrer, A. Bronson, D. Lacina., J. Graetz: “Spectroscopic and structural investigations of -, -, and -AlH3 phases”, Journal of Raman Spectroscopy, vol. 42(3), 512-516 (2011).

Studying transition metal chalcogenide alloys for infrared and solar cell device development

Relevant publication:

F.S. Manciu, J.G. Salazar, A. Diaz, S.A. Quinones: ”Spectroscopic, microscopic, and internal stress analysis in cadmium telluride grown by close-space sublimation", Thin Solid Films vol. 589, 298–302 (2015).

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